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Article

Enhanced motor cortex output and disinhibition in asymptomatic female mice with C9orf72 genetic expansion

1 Jul 2022

Abstract excerpt

Information and action coding by cortical circuits relies on a balanced dialogue between excitation and inhibition. Circuit hyperexcitability is considered a potential pathophysiological mechanism in various brain disorders, but the underlying deficits, especially at early disease stages, remain largely unknown. We report that asymptomatic female mice carrying the chromosome 9 open reading frame 72 (C9orf72)...

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PMID: 35793625
DOI: 10.1016/j.celrep.2022.111043

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