Article

Single-Molecule Nanopore Profiling of p53-TAD Conformational Dynamics, Interactions, and Inhibition

2026-08-29

Abstract excerpt

Investigating the conformational dynamics of intrinsically disordered proteins (IDPs) is essential to understanding how their structural heterogeneity underlies function and how their dysregulation contributes to diseases. Here, we utilized an MspA nanopore-based approach for studying the conformational dynamics and interactions of IDPs at the single-molecule level. The platform was demonstrated using the intrinsi...

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Literature Corpus work: a3f00ff9-053f-5f53-a675-1c311f12bd85
DOI: 10.64898/2026.08.28.747917

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