Article
Genetic mutation of TRPV2 induces anxiety by decreasing GABA-B R2 expression in hippocampus.
Biochemical and biophysical research communications - 10 Sept 2022
Liu Gaoyan, Liu Yamei, Niu Bowen, Zhou Yu, Peng Qingyu, Yan Jinyu, Tang Yunfei, Chen Fuxue, Li Feng, Feng Shini
Abstract excerpt
Transient receptor potential vanillic acid 2 (TRPV2) are well recognized for their contributions to neuronal development, cardiac function, immunity and cancer. However, the precise roles for this thermo TRPchannels in neurological disorder remain unknown. In this study, we employed the CRISPR/Cas9 system to generate genetic mutations of TRPV2. Genetic mutation of TRPV2 resulted in autistic-like phenotypes in...
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