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Article

Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma.

Scientific reports - 22 Jan 2020

Reese Rebecca M, Dourado Michelle, Anderson Keith, Warming Søren, Stark Kimberly L, Balestrini Alessia, Suto Eric, Lee Wyne, Riol-Blanco Lorena, Shields Shannon D, Hackos David H

Abstract excerpt

The transient receptor potential (TRP) superfamily of ion channels has garnered significant attention by the pharmaceutical industry. In particular, TRP channels showing high levels of expression in sensory neurons such as TRPV1, TRPA1, and TRPM8, have been considered as targets for indications where sensory neurons play a fundamental role, such as pain, itch, and asthma. Modeling these indications in rodents is...

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Identifiers

PMID: 31969645
DOI: 10.1038/s41598-020-57936-5
PMCID: PMC6976688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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