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Article

The role of ERK-1 and ERK-2 gene polymorphisms in PCOS pathogenesis.

Reproductive biology and endocrinology : RB&E - 29 Jun 2022

Guney Gurhan, Taşkın Mine Islimye, Sener Nazli, Tolu Ezgi, Dodurga Yavuz, Elmas Levent, Cetin Orkun, Sarigul Cengiz

Abstract excerpt

BACKGROUND: Ovulation is regulated by extracellular signal-regulated kinase-1 (ERK-1) and ERK-2 signaling mechanisms, and ERK-1/2 kinases modulates the function of most of the LH-regulated genes. Defective ERK kinase signaling that is secondary to a genetic problem contributes to both ovulatory dysfunction and metabolic problems in polycystic ovary syndrome (PCOS). We planned to investigate ERK-1 and ERK-2 gene...

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Identifiers

PMID: 35768803
DOI: 10.1186/s12958-022-00967-6
PMCID: PMC9241270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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