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Linking ABC transporters to the hallmarks of cancer

24 Oct 2023

Abstract excerpt

Human ATP-binding cassette (ABC) transporters are ubiquitously expressed and transport a broad range of endogenous and xenobiotic substrates across extra- and intracellular membranes. Mutations in ABC genes cause 21 monogenic diseases, and polymorphisms in these genes are associated with susceptibility to complex diseases. ABC transporters also play a major role in drug bioavailability, and they mediate multidrug...

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PMID: 37884430
DOI: 10.1016/j.trecan.2023.09.013

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