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Article

Pleiotropic Roles of ABC Transporters in Breast Cancer

21 Mar 2021

Abstract excerpt

Chemotherapeutics are the mainstay treatment for metastatic breast cancers. However, the chemotherapeutic failure caused by multidrug resistance (MDR) remains a pivotal obstacle to effective chemotherapies of breast cancer. Although in vitro evidence suggests that the overexpression of ATP-Binding Cassette (ABC) transporters confers resistance to cytotoxic and molecularly targeted chemotherapies by reducing the...

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PMID: 33801148
DOI: 10.3390/ijms22063199

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