Article
A machine learning model using SNPs obtained from a genome-wide association study predicts the onset of vincristine-induced peripheral neuropathy.
The pharmacogenomics journal - 1 Jul 2022
Yamada Hiroki, Ohmori Rio, Okada Naoto, Nakamura Shingen, Kagawa Kumiko, Fujii Shiro, Miki Hirokazu, Ishizawa Keisuke, Abe Masahiro, Sato Youichi
Abstract excerpt
Vincristine treatment may cause peripheral neuropathy. In this study, we identified the genes associated with the development of peripheral neuropathy due to vincristine therapy using a genome-wide association study (GWAS) and constructed a predictive model for the development of peripheral neuropathy using genetic information-based machine learning. The study included 72 patients admitted to the Department of...
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