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Article

Integrating variant functional annotation scores have varied abilities to improve power of genome-wide association studies.

Scientific reports - 24 Jun 2022

Gao Jianhui, Espin-Garcia Osvaldo, Paterson Andrew D, Sun Lei

Abstract excerpt

Functional annotations have the potential to increase power of genome-wide association studies (GWAS) by prioritizing variants according to their biological function, but this potential has not been well studied. We comprehensively evaluated all 1132 traits in the UK Biobank whose SNP-heritability estimates were given "medium" or "high" labels by Neale's lab. For each trait, we integrated GWAS summary statistics...

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PMID: 35750789
DOI: 10.1038/s41598-022-14924-1
PMCID: PMC9232605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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