Gene mutational profile of BRCAness and clinical implication in predicting response to platinum-based chemotherapy in patients with intrahepatic cholangiocarcinoma.

doi:10.1016/j.ejca.2022.05.004

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Article

Gene mutational profile of BRCAness and clinical implication in predicting response to platinum-based chemotherapy in patients with intrahepatic cholangiocarcinoma.

European journal of cancer (Oxford, England : 1990) - 1 Aug 2022

Rimini Margherita, Macarulla Teresa, Burgio Valentina, Lonardi Sara, Niger Monica, Scartozzi Mario, Rapposelli Ilario G, Aprile Giuseppe, Ratti Francesca, Pedica Federica, Verdaguer Helena, Nappo Floriana, Nichetti Federico, Lai Eleonora, Valgiusti Martina, Cappetta Alessandro, Febregat Carles, Fassan Matteo, De Braud Filippo, Puzzoni Marco, Frassineti Giovanni L, Simionato Francesca, De Cobelli Francesco, Aldrighetti Luca, Fornaro Lorenzo, Cascinu Stefano, Casadei-Gardini Andrea

Abstract excerpt

BACKGROUND AND AIMS: Biliary tract cancers are rare malignancies with a poor prognosis and scarce therapeutic strategies. The significance of BRCAness in this setting is already unknown. METHOD: Tissue specimens of BTC patients treated with platinum-based chemotherapy have been analyzed through the FOUNDATIONPne assay. RESULTS: 72/150 (48%) BRCAness mutated and 78/150 (52.0%) wild type (WT) patients were...

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PMID: 35749808
DOI: 10.1016/j.ejca.2022.05.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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