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Overexpression of efflux pump transporter genes and mutations in ERG11 pave the way to fluconazole resistance in Candida tropicalis: A study from a North India region.

Journal of global antimicrobial resistance - 1 Sept 2020

Pandey Nidhi, Tripathi Muktanand, Gupta Munesh K, Tilak Ragini

Abstract excerpt

INTRODUCTION: Fluconazole resistance in Candida tropicalis health care-associated infections is increasing. We investigated the role of efflux pump and mutations in ERG11p conferring fluconazole resistance in C. tropicalis. MATERIALS AND METHODS: A total of 17 C. tropicalis clinical isolates, including fluconazole-resistant and fluconazole-susceptible/fluconazole-susceptible dose-dependent isolates, were...

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Candida tropicalis
Candidiasis
Drug Resistance, Fungal
Fluconazole
Fungal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microbial Sensitivity Tests

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PMID: 32084606
DOI: 10.1016/j.jgar.2020.02.010

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