Article
Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells.
Oncogene - 21 Jul 2016
O'Hayre M, Inoue A, Kufareva I, Wang Z, Mikelis C M, Drummond R A, Avino S, Finkel K, Kalim K W, DiPasquale G, Guo F, Aoki J, Zheng Y, Lionakis M S, Molinolo A A, Gutkind J S
Abstract excerpt
G proteins and their cognate G protein-coupled receptors (GPCRs) function as critical signal transduction molecules that regulate cell survival, proliferation, motility and differentiation. The aberrant expression and/or function of these molecules have been linked to the growth, progression and metastasis of various cancers. As such, the analysis of mutations in the genes encoding GPCRs, G proteins and their...
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