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A post-translational modification of human Norovirus capsid protein attenuates glycan binding

21 Mar 2019

Abstract excerpt

Attachment of human noroviruses to histo blood group antigens (HBGAs) is essential for infection, but how this binding event promotes the infection of host cells is unknown. Here, we employ protein NMR experiments supported by mass spectrometry and crystallography to study HBGA binding to the P-domain of a prevalent virus strain (GII.4). We report a highly selective transformation of asparagine 373, located in an...

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PMID: 30899001
DOI: 10.1038/s41467-019-09251-5

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