Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insights into Siglec‐7 Binding to Gangliosides: NMR Protein Assignment and the Impact of Ligand Flexibility

26 Apr 2025

Abstract excerpt

Gangliosides, sialylated glycosphingolipids abundant in the nervous system, play crucial roles in neurotransmission, interaction with regulatory proteins, cell-cell recognition, and signaling. Altered gangliosides expression has been correlated with pathological processes, including cancer, inflammatory disorders, and autoimmune diseases. Gangliosides are important endogenous ligands of Siglecs (Sialic...

Topics

Join the communities discussing this publication.

Galectins and Cancer Biology
Glycosylation and Glycoproteins Research
Monoclonal and Polyclonal Antibodies Research

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40285643
DOI: 10.1002/advs.202415782

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insights into Siglec‐7 Binding to Gangliosides: NMR Protein Assignment and the Impact of Ligand FlexibilityPMID 40285643Read ↗

Prediction of Novel Disease-Related Regions in SIGLEC-7 by In Silico and Biochemical Analyses.Semantic proximity Read ↗

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockadeSemantic proximity Read ↗

An Integrative Approach to Develop and Characterise Antibodies Against the Cancer Associated Antigen Sialyl Lewis A (CA 19-9)Semantic proximity Read ↗

The biological role and immunotherapy of gangliosides and GD3 synthase in cancersSemantic proximity Read ↗

The glycan shield of alphaherpesvirus glycoprotein B modulates host co-receptor bindingSemantic proximity Read ↗

Sialylated glycoproteins suppress immune cell killing by binding to Siglec-7 and Siglec-9 in prostate cancerSemantic proximity Read ↗

Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and OpportunitiesSemantic proximity Read ↗

Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamilySemantic proximity Read ↗

Pathogen-sugar interactions revealed by universal saturation transfer analysis.Semantic proximity Read ↗

The Greater Affinity of JC Polyomavirus Capsid for α2,6-Linked Lactoseries Tetrasaccharide c than for Other Sialylated Glycans Is a Major Determinant of InfectivitySemantic proximity Read ↗

Cryptic pathogen-sugar interactions revealed by universal saturation transfer analysisSemantic proximity Read ↗

Molecular Mechanism of the Flexible Glycan Receptor Recognition by Mumps VirusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.