Article
NOD/RIPK2 signalling pathway contributes to osteoarthritis susceptibility.
Annals of the rheumatic diseases - 1 Oct 2022
Jurynec Michael J, Gavile Catherine M, Honeggar Matthew, Ma Ying, Veerabhadraiah Shivakumar R, Novak Kendra A, Hoshijima Kazuyuki, Kazmers Nikolas H, Grunwald David J
Abstract excerpt
OBJECTIVES: How inflammatory signalling contributes to osteoarthritis (OA) susceptibility is undetermined. An allele encoding a hyperactive form of the Receptor Interacting Protein Kinase 2 (RIPK2) proinflammatory signalling intermediate has been associated with familial OA. To test whether altered nucleotide-binding oligomerisation domain (NOD)/RIPK2 pathway activity causes heightened OA susceptibility, we...
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