Article
A hyperactivating proinflammatory RIPK2 allele associated with early-onset osteoarthritis.
Human molecular genetics - 1 Jul 2018
Jurynec Michael J, Sawitzke Allen D, Beals Timothy C, Redd Michael J, Stevens Jeff, Otterud Brith, Leppert Mark F, Grunwald David Jonah
Abstract excerpt
Osteoarthritis (OA) is a common debilitating disease characterized by abnormal remodeling of the cartilage and bone of the articular joint. Ameliorating therapeutics are lacking due to limited understanding of the molecular pathways affecting disease initiation and progression. Notably, although a link between inflammation and overt OA is well established, the role of inflammation as a driver of disease...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.