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Article

Pathogenic MAPT mutations Q336H and Q336R have isoform-dependent differences in aggregation propensity and microtubule dysfunction.

Journal of neurochemistry - 1 Jul 2021

Xia Yuxing, Nasif Lith, Giasson Benoit I

Abstract excerpt

Tauopathies are a group of heterogeneous neurodegenerative disorders characterized by brain deposition of tau inclusions. These insidious disorders include Alzheimer's disease and frontotemporal dementia, the two leading causes of dementia. Mutations in the microtubule-associated protein tau (MAPT) gene lead to familial forms of frontotemporal dementia. Previously, we used cell-based assays to screen over 20...

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PMID: 33772783
DOI: 10.1111/jnc.15358

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