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Article

Rapid assessment of SARS-CoV-2-evolved variants using virus-like particles.

Science (New York, N.Y.) - 24 Dec 2021

Syed Abdullah M, Taha Taha Y, Tabata Takako, Chen Irene P, Ciling Alison, Khalid Mir M, Sreekumar Bharath, Chen Pei-Yi, Hayashi Jennifer M, Soczek Katarzyna M, Ott Melanie, Doudna Jennifer A

Abstract excerpt

Efforts to determine why new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants demonstrate improved fitness have been limited to analyzing mutations in the spike (S) protein with the use of S-pseudotyped particles. In this study, we show that SARS-CoV-2 virus-like particles (SC2-VLPs) can package and deliver exogenous transcripts, enabling analysis of mutations within all structural proteins...

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Share to Coronavirus Nucleocapsid Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spike Glycoprotein, Coronavirus

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Source

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Identifiers

PMID: 34735219
DOI: 10.1126/science.abl6184
PMCID: PMC9005165

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