Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants.

doi:10.1038/s41598-018-25919-2

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Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants.

Scientific reports - 14 May 2018

Zhou Ang, Taylor Amy E, Karhunen Ville, Zhan Yiqiang, Rovio Suvi P, Lahti Jari, Sjögren Per, Byberg Liisa, Lyall Donald M, Auvinen Juha, Lehtimäki Terho, Kähönen Mika, Hutri-Kähönen Nina, Perälä Mia Maria, Michaëlsson Karl, Mahajan Anubha, Lind Lars, Power Chris, Eriksson Johan G, Raitakari Olli T, Hägg Sara, Pedersen Nancy L, Veijola Juha, Järvelin Marjo-Riitta, Munafò Marcus R, Ingelsson Erik, Llewellyn David J, Hyppönen Elina

Abstract excerpt

Coffee's long-term effect on cognitive function remains unclear with studies suggesting both benefits and adverse effects. We used Mendelian randomization to investigate the causal relationship between habitual coffee consumption and cognitive function in mid- to later life. This included up to 415,530 participants and 300,760 coffee drinkers from 10 meta-analysed European ancestry cohorts. In each cohort,...

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PMID: 29760501
DOI: 10.1038/s41598-018-25919-2
PMCID: PMC5951917

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