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Age-dependent patterns of schizophrenia genetic risk affect cognition.

Schizophrenia research - 1 Aug 2022

Kuo Susan S, Musket Christie W, Rupert Petra E, Almasy Laura, Gur Ruben C, Prasad Konasale M, Roalf David R, Gur Raquel E, Nimgaonkar Vishwajit L, Pogue-Geile Michael F

Abstract excerpt

Cognition shares substantial genetic overlap with schizophrenia, yet it remains unclear whether such genetic effects become significant during developmental periods of elevated risk for schizophrenia, such as the peak age of onset. We introduce an investigative framework integrating epidemiological, developmental, and genetic approaches to determine whether genetic effects shared between schizophrenia and...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Cognition
Humans
Middle Aged
Phenotype
Risk Factors
Schizophrenia
Young Adult

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PMID: 35709646
DOI: 10.1016/j.schres.2022.05.012
PMCID: PMC11227884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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