Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synthetic lethality in DNA repair network: A novel avenue in targeted cancer therapy and combination therapeutics

23 Nov 2017

Abstract excerpt

Synthetic lethality refers to a lethal phenotype that results from the simultaneous disruptions of two genes, while the disruption of either gene alone is viable. Many DNA double strand break repair (DSBR) genes have synthetic lethal relationships with oncogenes and tumor suppressor genes, which can be exploited for targeted cancer therapy, an approach referred to as combination therapy. DNA double-strand breaks...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29171189
DOI: 10.1002/iub.1696

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synthetic lethality in DNA repair network: A novel avenue in targeted cancer therapy and combination therapeuticsPMID 29171189Read ↗

DNA repair in cancer: emerging targets for personalized therapySemantic proximity Read ↗

Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation.Semantic proximity Read ↗

Synthetic lethality on drug discovery: an update on cancer therapy.Semantic proximity Read ↗

The power and the promise of synthetic lethality for clinical application in cancer treatmentSemantic proximity Read ↗

[Synthetic lethality as a new concept for the treatment of cancer].Semantic proximity Read ↗

Embracing synthetic lethality of novel anticancer therapies.Semantic proximity Read ↗

Synthetic lethality: exploiting the addiction of cancer to DNA repair.Semantic proximity Read ↗

Drugging the Cancers Addicted to DNA RepairSemantic proximity Read ↗

Harnessing DNA Double-Strand Break Repair for Cancer TreatmentSemantic proximity Read ↗

PARP inhibition as a prototype for synthetic lethal screens.Semantic proximity Read ↗

Targeting the DNA damage response in cancerSemantic proximity Read ↗

DNA Damage Repair Deficiency and Synthetic Lethality for Cancer Treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.