The causal relationship between sleep traits and the risk of schizophrenia: a two-sample bidirectional Mendelian randomization study.

doi:10.1186/s12888-022-03946-8

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Article

The causal relationship between sleep traits and the risk of schizophrenia: a two-sample bidirectional Mendelian randomization study.

BMC psychiatry - 15 Jun 2022

Wang Zhen, Chen Miao, Wei Yin-Ze, Zhuo Chen-Gui, Xu Hong-Fei, Li Wei-Dong, Ma Liang

Abstract excerpt

BACKGROUND: Observational studies suggest that sleep disturbances are commonly associated with schizophrenia. However, it is uncertain whether this relationship is causal. To investigate the bidirectional causal relation between sleep traits and schizophrenia, we performed a two-sample bidirectional Mendelian randomization (MR) study with the fixed effects inverse-variance weighted (IVW) method. METHODS: As...

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PMID: 35705942
DOI: 10.1186/s12888-022-03946-8
PMCID: PMC9202113

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