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Development of Combination Strategies for Focal Adhesion Kinase Inhibition in Diffuse Gastric Cancer

24 Oct 2022

Abstract excerpt

PURPOSE: Diffuse gastric cancer (DGC) is an aggressive and frequently lethal subtype of gastric cancer. Because DGC often lacks genomic aberrations that indicate clear candidate therapeutic targets, it has been challenging to develop targeted therapies for this gastric cancer subtype. Our previous study highlighted the contribution of focal adhesion kinase (FAK) in the tumorigenesis of DGC and the potential...

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PMID: 36278961
DOI: 10.1158/1078-0432.ccr-22-1609

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