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Article

Cortactin Facilitates Malignant Transformation of Dysplastic Cells in Gastric Cancer Development

1 Jan 2025

Abstract excerpt

BACKGROUND & AIMS: Epithelial cancer onset occurs through sequential stages of cell lineage conversion and functional dysregulation. Dysplasia is a precancerous lesion defined as a direct precursor to cancer and is histologically defined as a transition stage between pre-cancer and cancer, but molecular and biological mechanisms controlling its transformation to malignancy are underdetermined. Here, we discover...

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Identifiers

PMID: 40054524
DOI: 10.1016/j.jcmgh.2025.101490

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