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Article

Association Between Genetically Proxied Inhibition of HMG-CoA Reductase and Epithelial Ovarian Cancer.

JAMA - 18 Feb 2020

Yarmolinsky James, Bull Caroline J, Vincent Emma E, Robinson Jamie, Walther Axel, Smith George Davey, Lewis Sarah J, Relton Caroline L, Martin Richard M

Abstract excerpt

Importance: Preclinical and epidemiological studies indicate a potential chemopreventive role of statins in epithelial ovarian cancer risk. Objective: To evaluate the association of genetically proxied inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (ie, genetic variants related to lower function of HMG-CoA reductase, target of statins) with epithelial ovarian cancer among the general...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32068819
DOI: 10.1001/jama.2020.0150
PMCID: PMC7042851

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