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Article

De novo Biosynthesis of “Non‐Natural” Thaxtomin Phytotoxins

31 Mar 2018

Abstract excerpt

Thaxtomins are diketopiperazine phytotoxins produced by Streptomyces scabies and other actinobacterial plant pathogens that inhibit cellulose biosynthesis in plants. Due to their potent bioactivity and novel mode of action there has been considerable interest in developing thaxtomins as herbicides for crop protection. To address the need for more stable derivatives, we have developed a new approach for structural...

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PMID: 29603527
DOI: 10.1002/anie.201801525

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