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Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

24 Apr 2023

Abstract excerpt

Mechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T and B cell receptors (BCR) of >895,000 peripheral blood mononuclear cells from 73 coronavirus disease 2019 (COVID-19) patients and 75 healthy controls of Japanese ancestry with host genetic data. COVID-19 patients showed a low fraction of...

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PMID: 37095364
DOI: 10.1038/s41588-023-01375-1

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