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LMP1 Induces p53 Protein Expression via the H19/miR-675-5p Axis

8 Jun 2022

Abstract excerpt

Epstein-Barr virus (EBV) is the first virus to be known to have direct association with human cancer and to be considered as an important DNA tumor virus. The EBV life cycle consists of both latent and lytic modes of infection in B lymphocytes and epithelial cells. The persistence of EBV genomes in malignant cells promoted cell growth. p53, acting as a critical gatekeeper tumor suppressor, is involved in multiple...

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PMID: 35674441
DOI: 10.1128/spectrum.00006-22

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