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An Epstein-Barr virus–encoded microRNA targets PUMA to promote host cell survival

6 Oct 2008

Abstract excerpt

Epstein-Barr virus (EBV) is a herpesvirus associated with nasopharyngeal carcinoma (NPC), gastric carcinoma (GC), and other malignancies. EBV is the first human virus found to express microRNAs (miRNAs), the functions of which remain largely unknown. We report on the regulation of a cellular protein named p53 up-regulated modulator of apoptosis (PUMA) by an EBV miRNA known as miR-BART5, which is abundantly...

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PMID: 18838543
DOI: 10.1084/jem.20072581

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