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Modulation of LMP1 protein expression by EBV-encoded microRNAs

2 Oct 2007

Abstract excerpt

Epstein-Barr virus (EBV) was the first human virus found to encode microRNAs (miRNAs), but the function of these miRNAs has been obscure. Nasopharyngeal carcinoma (NPC) is associated with EBV infection, and the EBV-encoded LMP1 is believed to be a key factor in NPC development. However, detection of LMP1 protein in NPC is variable. Here, we report that EBV-encoded BART miRNAs target the 3' UTR of the LMP1 gene...

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PMID: 17911266
DOI: 10.1073/pnas.0702896104

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