Article
Revisiting the definition of glioma recurrence based on a phylogenetic investigation of primary and re-emerging tumor samples: a case report.
Brain tumor pathology - 1 Oct 2022
Umehara Toru, Arita Hideyuki, Miya Fuyuki, Achiha Takamune, Shofuda Tomoko, Yoshioka Ema, Kanematsu Daisuke, Nakagawa Tomoyoshi, Kinoshita Manabu, Kagawa Naoki, Fujimoto Yasunori, Hashimoto Naoya, Kiyokawa Hiroki, Morii Eiichi, Tsunoda Tatsuhiko, Kanemura Yonehiro, Kishima Haruhiko
Abstract excerpt
A recurrent tumor is defined as a re-emerging subclone originating from an ancestorial clone of the primary neoplasm. Hence, it should be distinguished from de novo tumor emerging from other clones. Herein, we describe an exceptional case in which the locally re-emerging glioma did not share genetic alterations of the primary tumor. While the initial tumor harbored mutations in IDH1 and TERT genes as well as...
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