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PAR2‐mediated cellular senescence promotes inflammation and fibrosis in aging and chronic kidney disease

30 Apr 2024

Abstract excerpt

Cellular senescence contributes to inflammatory kidney disease via the secretion of inflammatory and profibrotic factors. Protease-activating receptor 2 (PAR2) is a key regulator of inflammation in kidney diseases. However, the relationship between PAR2 and cellular senescence in kidney disease has not yet been described. In this study, we found that PAR2-mediated metabolic changes in renal tubular epithelial...

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PMID: 38687090
DOI: 10.1111/acel.14184

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