Article
Androgen signaling in adipose tissue, but less likely skeletal muscle, mediates development of metabolic traits in a PCOS mouse model.
American journal of physiology. Endocrinology and metabolism - 1 Aug 2022
Xiong Ting, Rodriguez Paris Valentina, Edwards Melissa C, Hu Ying, Cochran Blake J, Rye Kerry-Anne, Ledger William L, Padmanabhan Vasantha, Handelsman David J, Gilchrist Robert B, Walters Kirsty A
Abstract excerpt
Polycystic ovary syndrome (PCOS) is a common, multifactorial disorder characterized by endocrine, reproductive, and metabolic dysfunction. As the etiology of PCOS is unknown, there is no cure and symptom-oriented treatments are suboptimal. Hyperandrogenism is a key diagnostic trait, and evidence suggests that androgen receptor (AR)-mediated actions are critical to PCOS pathogenesis. However, the key AR target...
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