Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sarcopenia phenotype and impaired muscle function in male mice with fast-twitch muscle-specific knockout of the androgen receptor.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jan 2023

Hosoi Tatsuya, Yakabe Mitsutaka, Sasakawa Hiroko, Sasako Takayoshi, Ueki Kohjiro, Kato Shigeaki, Tokuoka Suzumi M, Oda Yoshiya, Abe Masahiro, Matsumoto Toshio, Akishita Masahiro, Ogawa Sumito

Abstract excerpt

Sarcopenia is distinct from normal muscle atrophy in that it is closely related to a shift in the muscle fiber type. Deficiency of the anabolic action of androgen on skeletal muscles is associated with sarcopenia; however, the function of the androgen receptor (AR) pathway in sarcopenia remains poorly understood. We generated a mouse model (fast-twitch muscle-specific AR knockout [fmARKO] mice) in which the AR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mice
Share to Mice, Knockout

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle Fibers, Fast-Twitch

Share to Muscle Fibers, Slow-Twitch

Share to Muscle, Skeletal

Share to Muscular Diseases

Share to Receptors, Androgen

Share to Sarcopenia

Source

Open in PubMed Open full text

Identifiers

PMID: 36669097
DOI: 10.1073/pnas.2218032120
PMCID: PMC9942915

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sarcopenia phenotype and impaired muscle function in male mice with fast-twitch muscle-specific knockout of the androgen receptor.PMID 36669097Read ↗

Androgen Action via the Androgen Receptor in Neurons Within the Brain Positively Regulates Muscle Mass in Male Mice.Semantic proximity Read ↗

Polyglutamine-expanded androgen receptor disrupts muscle triad, calcium dynamics and the excitation-contraction coupling gene expression programSemantic proximity Read ↗

Mouse sarcopenia model reveals sex- and age-specific differences in phenotypic and molecular characteristics.Semantic proximity Read ↗

Research Resource: The Androgen Receptor Modulates Expression of Genes with Critical Roles in Muscle Development and FunctionSemantic proximity Read ↗

Androgen signaling in adipose tissue, but less likely skeletal muscle, mediates development of metabolic traits in a PCOS mouse model.Semantic proximity Read ↗

An integrated study of hormone-related sarcopenia for modeling and comparative transcriptome in ratsSemantic proximity Read ↗

Androgen receptor determines skeletal muscle sexual dimorphismSemantic proximity Read ↗

Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy.Semantic proximity Read ↗

Defective excitation-contraction coupling and mitochondrial respiration precede mitochondrial Ca2+ accumulation in spinobulbar muscular atrophy skeletal muscleSemantic proximity Read ↗

<i>ACTN3</i> genotype influences androgen response in skeletal muscleSemantic proximity Read ↗

Lifelong dietary protein restriction induces denervation and skeletal muscle atrophy in miceSemantic proximity Read ↗

Spinal and bulbar muscular atrophy: From molecular pathogenesis to pharmacological intervention targeting skeletal muscleSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.