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Article

Effect of mutations across reverse transcriptase region on HBV replication and progression of liver diseases in Chinese patients.

Journal of clinical laboratory analysis - 1 Jul 2022

Lai Xiaoqin, Chen Wenfa, Wu Yuzhu, Gao Yali, Zhang Yalan, Xu Xuwei, Fu Ya, Wang Xinwen, Yang Yanbing, Zhang Yin

Abstract excerpt

It was known that mutations in the RT region were mainly related to nucleot(s)ide analogs resistance. Increasing studies indicated that RT mutations were related to advanced liver diseases (ALD) and had effects on HBV replication, but the distribution characteristics of mutations across RT region in the development of liver diseases and the effect of RT mutations on HBV replication were not fully clarified. HBV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35657116
DOI: 10.1002/jcla.24530
PMCID: PMC9279987

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