Article
Accumulation of mutations in reverse transcriptase of hepatitis B virus is associated with liver disease severity in treatment-naïve Chinese patients with chronic hepatitis B.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University - 1 Oct 2017
Zhu Bin, Wang Tianbao, Wei Xiaoxia, Zhuo Ya, Liu Amin, Zhang Guangwen
Abstract excerpt
BACKGROUND: Mutations in reverse transcriptase (RT) of the hepatitis B virus (HBV) are demonstrated to be strongly associated with nucleos(t)ide analog resistance, which is supposed to be the biggest obstacle during the long-term anti-viral treatment of chronic hepatitis B. However, the presence of RT mutations in treatment-naïve chronic hepatitis B patients and its clinical significance are not well known....
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