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Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naïve Chinese patients.

Antiviral research - 1 Mar 2010

Liu Bao-Ming, Li Tong, Xu Jie, Li Xiao-Guang, Dong Jian-Ping, Yan Ping, Yang Jing-Xian, Yan Ling, Gao Zhi-Yong, Li Wen-Peng, Sun Xie-Wen, Wang Yu-Hua, Jiao Xiu-Juan, Hou Chun-Sheng, Zhuang Hui

Abstract excerpt

Full-length hepatitis B virus (HBV) reverse transcriptase (RT) sequences were amplified and sequenced among 192 nucleos(t)ide analogue (NA)-naïve Chinese patients with chronic hepatitis B. Deduced amino acids (AAs) at 42 previously reported potential NA resistance (NAr) mutation positions in RT region were analyzed. Patients were found with either B-genotype (28.65%) or C-genotype (71.35%) infections. Rt53, rt91,...

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Share to Amino Acid Substitution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20034521
DOI: 10.1016/j.antiviral.2009.12.006

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