Article
Nucleos(t)ide analogues causes HBV S gene mutations and carcinogenesis.
Hepatobiliary & pancreatic diseases international : HBPD INT - 1 Dec 2016
Wang Meng-Lan, Tang Hong
Abstract excerpt
BACKGROUND: The long-term use of nucleos(t)ide analogues causes drug resistance and mutations in the HBV reverse transcriptase (RT) region of the polymerase gene. The RT region overlaps the HBV surface gene (S gene) and therefore, the mutations in the RT region simultaneously modify S gene sequence. Certain mutations in the RT region bring about truncated S proteins because the corresponding changed S gene...
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