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Article

Convergent evolution and multi-wave clonal invasion in H3 K27-altered diffuse midline gliomas treated with a PDGFR inhibitor.

Acta neuropathologica communications - 31 May 2022

Arunachalam Sasi, Szlachta Karol, Brady Samuel W, Ma Xiaotu, Ju Bensheng, Shaner Bridget, Mulder Heather L, Easton John, Raphael Benjamin J, Myers Matthew, Tinkle Christopher, Allen Sariah J, Orr Brent A, Wetmore Cynthia J, Baker Suzanne J, Zhang Jinghui

Abstract excerpt

The majority of diffuse midline gliomas, H3 K27-altered (DMG-H3 K27-a), are infiltrating pediatric brain tumors that arise in the pons with no effective treatment. To understand how clonal evolution contributes to the tumor's invasive spread, we performed exome sequencing and SNP array profiling on 49 multi-region autopsy samples from 11 patients with pontine DMG-H3 K27-a enrolled in a phase I clinical trial of...

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Identifiers

PMID: 35642016
DOI: 10.1186/s40478-022-01381-0
PMCID: PMC9153212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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