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Article

Reactivation of p53 by RITA Induces Apoptosis in Human Oral Squamous Cell Carcinoma Cells

31 May 2022

Abstract excerpt

BACKGROUND/AIM: Oral squamous cell carcinoma (OSCC) is one of the most common tumors of the head and neck region. The tumor suppressor gene p53 (TP53) is the most frequently mutated gene in OSCC and TP53 mutations are associated with decreased survival and resistance to chemotherapy in patients with OSCC. Therefore, therapeutic strategies targeting TP53 reactivation are required to effectively treat OSCC. In this...

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PMID: 35641264
DOI: 10.21873/anticanres.15775

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Reactivation of p53 by RITA Induces Apoptosis in Human Oral Squamous Cell Carcinoma CellsPMID 35641264Read ↗

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