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Article

Interplay of p62-mTORC1 and EGFR signaling promotes cisplatin resistance in oral cancer

1 Mar 2024

Abstract excerpt

Cisplatin resistance poses a major challenge in the treatment of oral squamous cell carcinoma (OSCC). Deeper investigations into the mechanisms underlying this drug resistance is of great importance. Here, we used cellular assays and clinical immunohistochemistry to examine molecular pathways involved in both innate and acquired cisplatin resistance. We demonstrated that the p62-mTORC1 signaling complex plays a...

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PMID: 38560690
DOI: 10.1016/j.heliyon.2024.e28406

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