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Mitosis of hepatitis B virus-infected cells in vitro results in uninfected daughter cells

15 Jun 2022

Abstract excerpt

Background & Aims The chronicity of HBV (and resultant liver disease) is determined by intrahepatic persistence of the HBV covalently closed circular DNA (cccDNA), an episomal form that encodes all viral transcripts. Therefore, cccDNA is a key target for new treatments, with the ultimate therapeutic aim being its complete elimination. Although established cccDNA molecules are known to be stable in resting...

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PMID: 35898957
DOI: 10.1016/j.jhepr.2022.100514

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