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Generation and characterization of a stable cell line persistently replicating and secreting the human hepatitis delta virus

10 Jul 2019

Abstract excerpt

Human hepatitis delta virus (HDV) causes the most severe form of viral hepatitis. Approximately 15-25 million people are chronically infected with HDV. As a satellite virus of the human hepatitis B virus (HBV), HDV uses the HBV-encoded envelope proteins for egress from and de novo entry into hepatocytes. So far, in vitro production of HDV particles is restricted to co-transfection of cells with HDV/HBV encoding...

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PMID: 31292511
DOI: 10.1038/s41598-019-46493-1

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