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The TNNT2:c.95-108G>A variant is common in Maine Coons and shows no association with hypertrophic cardiomyopathy.

Animal genetics - 1 Aug 2022

Schipper Tom, Ohlsson Åsa, Longeri Maria, Hayward Jessica J, Mouttham Lara, Ferrari Paolo, Smets Pascale, Ljungvall Ingrid, Häggström Jens, Stern Joshua A, Lyons Leslie A, Peelman Luc J, Broeckx Bart J G

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is a common and potentially fatal heart disease in many cat breeds. An intronic variant in TNNT2, c.95-108G>A, was recently reported as the cause of HCM in the Maine Coon. The aim of this study was to determine this variant's allele frequency in different populations and its possible association with HCM. Based on 160 Maine Coon samples collected in Belgium, Italy, Sweden and the...

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PMID: 35634705
DOI: 10.1111/age.13223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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