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Article

Identification of novel genetic variants associated with feline cardiomyopathy using targeted next-generation sequencing.

Scientific reports - 31 Jan 2025

Raffle Jade, Novo Matos Jose, Wallace Marsha, Wilkie Lois, Piercy Richard J, Elliott Perry, Connolly David J, Luis Fuentes Virginia, Psifidi Androniki

Abstract excerpt

Cardiomyopathies are the most common heritable heart diseases in cats and humans. This study aimed to identify novel genetic variants in cats with hypertrophic cardiomyopathy (HCM) and restrictive cardiomyopathy (RCM) using a targeted panel of genes associated with human cardiomyopathy. Cats were phenotyped for HCM/RCM by echocardiography ± necropsy. DNA was extracted from residual blood, and targeted...

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Source

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Identifiers

PMID: 39890868
DOI: 10.1038/s41598-025-87852-5
PMCID: PMC11785968

Genes

ACTC1
ACTN2
CSRP3
MYH7
TNNT2

Provenance

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