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Precision medicine validation: identifying the MYBPC 3 A31P variant with whole-genome sequencing in two Maine Coon cats with hypertrophic cardiomyopathy

18 Dec 2018

Abstract excerpt

Objectives The objective of this study was to perform a proof-of-concept experiment that validates a precision medicine approach to identify variants associated with hypertrophic cardiomyopathy (HCM). We hypothesized that whole-genome sequencing would identify variant(s) associated with HCM in two affected Maine Coon/Maine Coon cross cats when compared with 79 controls of various breeds. Methods Two affected and...

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Cardiomyopathy and Myosin Studies
Cardiovascular Conditions and Treatments
Congenital heart defects research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30558461
DOI: 10.1177/1098612x18816460

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Precision medicine validation: identifying the MYBPC 3 A31P variant with whole-genome sequencing in two Maine Coon cats with hypertrophic cardiomyopathyPMID 30558461Read ↗

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Association of A31P and A74T polymorphisms in the myosin binding protein C3 gene and hypertrophic cardiomyopathy in Maine Coon and other breed cats.Semantic proximity Read ↗

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