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Article

Prevalence of the myosin-binding protein C mutation in Maine Coon cats.

Journal of veterinary internal medicine - 1 Jan 2000

Fries R, Heaney A M, Meurs K M

Abstract excerpt

BACKGROUND: An autosomal dominant mutation has been identified in the myosin-binding protein C (MYBPC3) gene of Maine Coon cats. This mutation changes a conserved amino acid and computationally alters the protein conformation of this gene in Maine Coon cats with hypertrophic cardiomyopathy. The prevalence of this mutation is unknown. OBJECTIVE: To determine the genetic prevalence of the MYBPC3 mutation in a large...

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Source

Identifiers

PMID: 18498321
DOI: 10.1111/j.1939-1676.2008.0113.x

Genes

MYBPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Prevalence of the myosin-binding protein C mutation in Maine Coon cats.PMID 18498321Read ↗

Myosin-binding protein C DNA variants in domestic cats (A31P, A74T, R820W) and their association with hypertrophic cardiomyopathy.Semantic proximity Read ↗

Prevalence and demographics of the MYBPC3-mutations in ragdolls and Maine coons in the British Isles.Semantic proximity Read ↗

Association of A31P and A74T polymorphisms in the myosin binding protein C3 gene and hypertrophic cardiomyopathy in Maine Coon and other breed cats.Semantic proximity Read ↗

Prevalence of the MYBPC3-A31P mutation in a large European feline population and association with hypertrophic cardiomyopathy in the Maine Coon breed.Semantic proximity Read ↗

Hypertrophic cardiomyopathy in young Maine Coon cats caused by the p.A31P cMyBP-C mutation--the clinical significance of having the mutation.Semantic proximity Read ↗

Absence of known feline MYH7 and MYBPC3 variants in a diverse cohort of cats with hypertrophic cardiomyopathy.Semantic proximity Read ↗

Classification of feline hypertrophic cardiomyopathy-associated gene variants according to the American College of Medical Genetics and Genomics guidelinesSemantic proximity Read ↗

Genotype-phenotype correlation between the cardiac myosin binding protein C mutation A31P and hypertrophic cardiomyopathy in a cohort of Maine Coon cats: a longitudinal study.Semantic proximity Read ↗

Precision medicine validation: identifying the MYBPC 3 A31P variant with whole-genome sequencing in two Maine Coon cats with hypertrophic cardiomyopathySemantic proximity Read ↗

A cardiac myosin binding protein C mutation in the Maine Coon cat with familial hypertrophic cardiomyopathy.Semantic proximity Read ↗

Prospective echocardiographic and tissue Doppler imaging screening of a population of Maine Coon cats tested for the A31P mutation in the myosin-binding protein C gene: a specific analysis of the heterozygous status.Semantic proximity Read ↗

A novel homozygous premature stop mutation in TNNT2 associates with Feline cardiomyopathySemantic proximity Read ↗

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