Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myosin-binding protein C DNA variants in domestic cats (A31P, A74T, R820W) and their association with hypertrophic cardiomyopathy.

Journal of veterinary internal medicine - 1 Jan 2000

Longeri M, Ferrari P, Knafelz P, Mezzelani A, Marabotti A, Milanesi L, Pertica G, Polli M, Brambilla P G, Kittleson M, Lyons L A, Porciello F

Abstract excerpt

BACKGROUND: Two mutations in the MYBPC3 gene have been identified in Maine Coon (MCO) and Ragdoll (RD) cats with hypertrophic cardiomyopathy (HCM). OBJECTIVE: This study examined the frequency of these mutations and of the A74T polymorphism to describe their worldwide distribution and correlation with echocardiography. ANIMALS: 1855 cats representing 28 breeds and random-bred cats worldwide, of which 446...

Topics

Join the communities discussing this publication.

Cardiomyopathy, Hypertrophic
Carrier Proteins
Cat Diseases
Cats
Cross-Sectional Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Echocardiography

Source

Open in PubMed Open full text

Identifiers

PMID: 23323744
DOI: 10.1111/jvim.12031
PMCID: PMC3602388

Genes

MYBPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myosin-binding protein C DNA variants in domestic cats (A31P, A74T, R820W) and their association with hypertrophic cardiomyopathy.PMID 23323744Read ↗

Association of A31P and A74T polymorphisms in the myosin binding protein C3 gene and hypertrophic cardiomyopathy in Maine Coon and other breed cats.Semantic proximity Read ↗

Hypertrophic cardiomyopathy in young Maine Coon cats caused by the p.A31P cMyBP-C mutation--the clinical significance of having the mutation.Semantic proximity Read ↗

Prevalence of the myosin-binding protein C mutation in Maine Coon cats.Semantic proximity Read ↗

Classification of feline hypertrophic cardiomyopathy-associated gene variants according to the American College of Medical Genetics and Genomics guidelinesSemantic proximity Read ↗

Prevalence of the MYBPC3-A31P mutation in a large European feline population and association with hypertrophic cardiomyopathy in the Maine Coon breed.Semantic proximity Read ↗

Genotype-phenotype correlation between the cardiac myosin binding protein C mutation A31P and hypertrophic cardiomyopathy in a cohort of Maine Coon cats: a longitudinal study.Semantic proximity Read ↗

Absence of known feline MYH7 and MYBPC3 variants in a diverse cohort of cats with hypertrophic cardiomyopathy.Semantic proximity Read ↗

Precision medicine validation: identifying the MYBPC 3 A31P variant with whole-genome sequencing in two Maine Coon cats with hypertrophic cardiomyopathySemantic proximity Read ↗

Prospective echocardiographic and tissue Doppler imaging screening of a population of Maine Coon cats tested for the A31P mutation in the myosin-binding protein C gene: a specific analysis of the heterozygous status.Semantic proximity Read ↗

A novel homozygous premature stop mutation in TNNT2 associates with Feline cardiomyopathySemantic proximity Read ↗

The Maine Coon Cat Harboring the MYBPC3-A31P Mutation: A Genotype-Stratified Phenotypic Characterization of Hypertrophic CardiomyopathySemantic proximity Read ↗

Prevalence and demographics of the MYBPC3-mutations in ragdolls and Maine coons in the British Isles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.