Article
Genetic Variability of Inflammation and Oxidative Stress Genes Affects Onset, Progression of the Disease and Survival of Patients with Amyotrophic Lateral Sclerosis.
Genes - 25 Apr 2022
Ravnik-Glavač Metka, Goričar Katja, Vogrinc David, Koritnik Blaž, Lavrenčič Jakob Gašper, Glavač Damjan, Dolžan Vita
Abstract excerpt
Inflammation and oxidative stress are recognized as important contributors to amyotrophic lateral sclerosis (ALS) disease pathogenesis. Our aim was to evaluate the impact of selected single-nucleotide polymorphisms in genes involved in inflammation and oxidative stress on ALS susceptibility and modification. One-hundred-and-eighty-five ALS patients and 324 healthy controls were genotyped for nine polymorphisms in...
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