Article
IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients.
Journal of neuroinflammation - 9 Nov 2010
Fiala Milan, Chattopadhay Madhuri, La Cava Antonio, Tse Eric, Liu Guanghao, Lourenco Elaine, Eskin Ascia, Liu Philip T, Magpantay Larry, Tse Stephen, Mahanian Michelle, Weitzman Rachel, Tong Jason, Nguyen Caroline, Cho Tiffany, Koo Patrick, Sayre James, Martinez-Maza Otoniel, Rosenthal Mark J, Wiedau-Pazos Martina
Abstract excerpt
The contribution of inflammation to neurodegenerative diseases is increasingly recognized, but the role of inflammation in sporadic amyotrophic lateral sclerosis (sALS) is not well understood and no animal model is available. We used enzyme-linked immunosorbent assays (ELISAs) to measure the cytokine interleukin-17A (IL-17A) in the serum of ALS patients (n = 32; 28 sporadic ALS (sALS) and 4 familial ALS (fALS))...
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